Building the information layer of health through biomolecular causality

We are biology, studying itself.

Descend Source
you I’m tired all the time.
Fatigue
agent How do you sleep? And any bleeding — heavy periods, anything like that?
you Badly. My partner says I snore. And yes, heavy.
Snoring Menorrhagia “badly” Sleep Apnea Syndromes Pain, Postoperative Hypothermia Acidosis Abortion, Spontaneous Stroke
agent Do you eat much meat? And has your weight changed at all, without you meaning it to?
you Not much meat. Gained, without changing anything.
Weight Gain “not much meat” Apnea Sleep Apnea, Obstructive Atherosclerosis Hypothyroidism Adenomyosis Pediatric Obesity Virus Diseases Infertility Stroke
agent How long has this been going on?
you More than a year.
“more than a year” Hyperandrogenism Hyperprolactinemia Dysbiosis Liver Cirrhosis, Experimental Ventricular Remodeling
agent Two things you can start now, and they’re safe: walk, daily; less alcohol, if you drink. Before guessing further I’d want a TSH. Which of those is easiest for you?
walk, daily less alcohol, if you drink TSH
you I wore a sleep tracker for a week.
wearable
agent Your oxygen dips at night, and your sleep is broken up. I still want the blood.
you Got the blood panel back.
blood panel
agent Iron stores near empty — ferritin 9, deficient under 30. Blood count still holds. Thyroid a little slow — TSH 6.1, just over the line. Recheck, not treat. B12 fine. Periods are where the iron goes. They need their own look.
you I had my genome done last year.
genome methylation clock
agent Nothing on IGSF1, so the TSH is one to trust. TMPRSS6 carries a variant — iron by mouth may not absorb. If the ferritin will not climb on the plate, it is an infusion conversation. Nothing here changes the sleep.
the dish how much of the fatigue is the apnea, and how much the iron
unearned

A cause is earned on living cells. Change something. Watch.

Section view of one Aevum row: pipette above a septum mat, four plate tiles under one shared headspace, the observer head in the dry bay below on the OT-2 deck. Wells are pressed, the headspace cycled, heads swapped, and wells read in turn.OT-2 deck · dry kinematic referencedry inverted bay · 80 mmdock plane · heads swap hereobserver · label-freeseptum matshared headspace · CO₂ / RH / O₂ · one continuous volumesupplyCO₂ · O₂ · N₂returnP300 · through the septum, 1.5 mm off the imaging axis

now first fixture commissioned on an OT-2 · one-row coupon in revision · CERN-OHL-S-2.0 Aeon-Bio/aevum

Founders

Eric Jing Mockler

CEO · cofounder

Bioengineering, cognitive science, neuroscience at UC Santa Cruz. Variant discovery across 10,000+ genomes at Gladstone and Answer ALS. With the Gyori lab, the belief model: does the paper actually say this causes that.

Karen Sachs, PhD

CSO/CTO · cofounder

MIT PhD, biological engineering. Stanford Medicine postdoc. Causal networks from single-cell perturbation data; Science Breakthrough of the Year runner-up. 60+ papers.