Building the information layer of health through biomolecular causality

Decode mechanisms. Prevent disease.

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Why current approaches fall short

Healthcare generates unprecedented data—genomics, transcriptomics, epigenomics, metabolomics, biometrics—yet these remain fragmented and underutilized.

Current AI approaches find correlations in this data. But correlation isn't causation. Without understanding why a molecular pattern leads to disease, recommendations remain guesswork.

The Correlation Trap

Traditional approaches find statistical associations but miss the underlying mechanisms. High correlation doesn't guarantee causation—leading to ineffective interventions based on spurious relationships.

True Causal Understanding

Aeon Bio maps direct biomolecular pathways from molecular state through biological functions to health outcomes, revealing actionable mechanisms you can influence.

Aeon Bio changes this.

Factor graphs meet multi-omics data

We integrate multi-omics data (genomic, epigenetic, metabolomic, biometric) with scientific literature through factor graphs—probabilistic models that map causal relationships at every biological scale.

Think of it as a living map of human biology:

Molecules → observed from your data (genes, metabolites, proteins)
Biological functions → learned from 150,000+ research papers
Causal pathways → inferred through belief propagation
Health outcomes → predicted years before clinical symptoms

Unlike foundation models that pattern-match, our approach reasons about why molecular states lead to specific health trajectories. Every recommendation traces back to a causal mechanism.

Beyond Foundation Models

We use foundation models as probability distributions—inputs to our factor graphs, not endpoints. This enables true causal reasoning instead of sophisticated correlation.

From molecules to medicine

Disease Prevention

Detect disease-trending processes before clinical symptoms

Traditional diagnostics catch disease after damage occurs. Our causal models identify molecular trajectories toward inflammation, metabolic syndrome, and cardiovascular disease years earlier—when intervention is most effective.

Personalized Interventions

Recommendations rooted in your molecular causality

Rather than generic advice, we trace your specific molecular state through biological pathways to identify personalized interventions—lifestyle changes, supplements, therapies—with clear mechanistic rationale.

Research & Development

Partner to build custom causal models for your data

We create specialized factor graph models tailored to specific data modalities: genomic variants, methylation patterns, metabolomics, clinical biomarkers. Each implementation strengthens the network for all partners.

Build the future of precision health with us

Co-Development Partnerships

Collaborate on novel applications of causal biomolecular modeling. We bring the factor graph infrastructure and causal AI expertise—you bring domain knowledge and data.

Ideal for: Biotech companies, longevity clinics, research institutions exploring new therapeutic targets.

Data Partnerships

Provide specialized data modalities (methylation, proteomics, clinical outcomes) to help build and validate causal models. Gain insights from the resulting models.

Ideal for: Testing companies, health platforms with unique datasets, clinical research organizations.

Research Collaborations

Joint research initiatives to advance the science of biomolecular causality and precision health.

Ideal for: Academic labs, consortium partners, organizations pushing the boundaries of computational biology.

Built on pioneering research in causal AI

Eric Jing Mockler – CEO & Cofounder

  • UC Santa Cruz: Bioengineering, Cognitive Science, Neuroscience
  • Architected genomic pipelines processing 10,000+ genomes (Gladstone Institutes, AnswerALS consortium)
  • Open-source contributor to causal genomics methods
  • Specializes in scalable bioinformatics infrastructure

Karen Sachs, PhD – CSO/CTO & Cofounder

  • MIT PhD in Biological Engineering, Stanford Medicine postdoc
  • Pioneer in single-cell causal inference and CyTOF technology
  • 60+ publications, 8,000+ citations
  • Science Breakthrough of the Year runner-up
  • $2.5M SBIR grant for Causal AI drug development

Ready to explore what's possible?

Whether you're developing precision therapeutics, building health platforms, or advancing longevity science—Aeon Bio's causal modeling infrastructure can accelerate your work.

Let's discuss how biomolecular causality can transform your approach to human health.